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Article 126 of 244

The use and analysis of microarray data
Butte A
NATURE REVIEWS DRUG DISCOVERY

1 (12): 951-960 DEC 2002

Document type: Review

Language: English

Cited References: 52

Times Cited: 7

Abstract:
Functional genomics is the study of gene function through the parallel expression measurements of genomes, most commonly using the technologies of microarrays and serial analysis of gene expression. Microarray usage in drug discovery is expanding, and its applications include basic research and target discovery, biomarker determination, pharmacology, toxicogenomics, target selectivity, development of prognostic tests and disease-subclass determination. This article reviews the different ways to analyse large sets of microarray data, including the questions that can be asked and the challenges in interpreting the measurements.

KeyWords Plus:
GENE-EXPRESSION DATA, SELF-ORGANIZING MAPS, SACCHAROMYCES-CEREVISIAE, RELEVANCE NETWORKS, PATTERNS, CLASSIFICATION, CANCER, HYBRIDIZATION, DISCOVERY, ARRAYS

Addresses:
Butte A, Childrens Hosp, Informat Program, 300 Longwood Ave, Boston, MA 02115 USA
Childrens Hosp, Informat Program, Boston, MA 02115 USA
Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA

Publisher:
NATURE PUBLISHING GROUP, LONDON

IDS Number:
620WB

Article 126 of 244

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